Protein Details: Volume-regulated anion channel subunit LRRC8B
Protein ID
ICDB_Pro_0976
Protein Name
Volume-regulated anion channel subunit LRRC8B
Gene Name
Lrrc8b; Kiaa0231
Organism
Mus musculus (Mouse)
Length
803 amino acids
AlphaFoldDB
AF-Q5DU41-F1-model_v4.pdb
Function
Non-essential component of the volume-regulated anion channel (VRAC; also named VSOAC channel); an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B; LRRC8C; LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Sequence
MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDNQCAVPWDLLKGSENASSNSGLLLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLLSTSGGSADIDASKQSLPYPQPGLESPGIESPTSSVLDKKEGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVMLYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVERLKSKLVKNSQDKVELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPAAVAQLVNLRELHVYHSSLVVDHPALAFLEENLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEIISFQHLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELTGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPLPVAERLQTCLDKC
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
RefSeq
NP_001028722.1 [Q5DU41-1]; XP_011247810.1 [Q5DU41-1]